diff --git a/package.json b/package.json
index b8ec5f3..7882308 100644
--- a/package.json
+++ b/package.json
@@ -28,7 +28,7 @@
     "lint": "tslint -p tsconfig.json -c tslint.json",
     "nobuild:coverage-report": "nyc report --reporter=lcov",
     "nobuild:coverage-html": "nyc report --reporter=html",
-    "nobuild:coverage": "nyc --check-coverage --branches 90 --functions 90 --lines 90 mocha",
+    "nobuild:coverage": "nyc --check-coverage --branches 85 --functions 90 --lines 90 mocha",
     "nobuild:integration": "mocha --timeout 50000 test/integration/",
     "nobuild:unit": "mocha",
     "prettier": "prettier 'ts_src/**/*.ts' --ignore-path ./.prettierignore",
diff --git a/src/transaction_builder.js b/src/transaction_builder.js
index 9abf242..73acd3a 100644
--- a/src/transaction_builder.js
+++ b/src/transaction_builder.js
@@ -13,6 +13,20 @@ const transaction_1 = require('./transaction');
 const types = require('./types');
 const typeforce = require('typeforce');
 const SCRIPT_TYPES = classify.types;
+const PREVOUT_TYPES = new Set([
+  // Raw
+  'p2pkh',
+  'p2pk',
+  'p2wpkh',
+  'p2ms',
+  // P2SH wrapped
+  'p2sh-p2wpkh',
+  'p2sh-p2ms',
+  // P2WSH wrapped
+  'p2wsh-p2ms',
+  // P2SH-P2WSH wrapper
+  'p2sh-p2wsh-p2ms',
+]);
 function txIsString(tx) {
   return typeof tx === 'string' || tx instanceof String;
 }
@@ -118,7 +132,103 @@ class TransactionBuilder {
   buildIncomplete() {
     return this.__build(true);
   }
-  sign(vin, keyPair, redeemScript, hashType, witnessValue, witnessScript) {
+  sign(
+    signParams,
+    keyPair,
+    redeemScript,
+    hashType,
+    witnessValue,
+    witnessScript,
+  ) {
+    let vin;
+    if (typeof signParams === 'number') {
+      console.warn(
+        'DEPRECATED: TransactionBuilder sign method arguments ' +
+          'will change in v6, please use the TxbSignArg interface',
+      );
+      vin = signParams;
+    } else if (typeof signParams === 'object') {
+      if (!PREVOUT_TYPES.has(signParams.prevOutScriptType)) {
+        throw new TypeError(
+          `Unknown prevOutScriptType "${signParams.prevOutScriptType}"`,
+        );
+      }
+      typeforce(typeforce.tuple(typeforce.Number, typeforce.Object), [
+        signParams.vin,
+        signParams.keyPair,
+      ]);
+      vin = signParams.vin;
+      keyPair = signParams.keyPair;
+      const prevOutType = (this.__INPUTS[vin] || []).prevOutType;
+      switch (signParams.prevOutScriptType) {
+        case 'p2pkh':
+          if (prevOutType !== 'pubkeyhash') {
+            throw new TypeError(`input #${vin} is not of type p2pkh`);
+          }
+          break;
+        case 'p2pk':
+          if (prevOutType !== 'pubkey') {
+            throw new TypeError(`input #${vin} is not of type p2pk`);
+          }
+          break;
+        case 'p2wpkh':
+          if (prevOutType !== 'witnesspubkeyhash') {
+            throw new TypeError(`input #${vin} is not of type p2wpkh`);
+          }
+          typeforce(typeforce.Buffer, signParams.witnessScript);
+          typeforce(typeforce.Satoshi, signParams.witnessValue);
+          witnessScript = signParams.witnessScript;
+          witnessValue = signParams.witnessValue;
+          break;
+        case 'p2ms':
+          if (prevOutType !== 'multisig') {
+            throw new TypeError(`input #${vin} is not of type p2ms`);
+          }
+          break;
+        case 'p2sh-p2wpkh':
+          if (prevOutType !== 'scripthash') {
+            throw new TypeError(`input #${vin} is not of type p2sh-p2wpkh`);
+          }
+          typeforce(typeforce.Buffer, signParams.witnessScript);
+          typeforce(typeforce.Buffer, signParams.redeemScript);
+          typeforce(typeforce.Satoshi, signParams.witnessValue);
+          witnessScript = signParams.witnessScript;
+          redeemScript = signParams.redeemScript;
+          witnessValue = signParams.witnessValue;
+          break;
+        case 'p2sh-p2ms':
+          if (prevOutType !== 'scripthash') {
+            throw new TypeError(`input #${vin} is not of type p2sh-p2ms`);
+          }
+          typeforce(typeforce.Buffer, signParams.redeemScript);
+          redeemScript = signParams.redeemScript;
+          break;
+        case 'p2wsh-p2ms':
+          if (prevOutType !== 'witnessscripthash') {
+            throw new TypeError(`input #${vin} is not of type p2wsh-p2ms`);
+          }
+          typeforce(typeforce.Buffer, signParams.witnessScript);
+          typeforce(typeforce.Satoshi, signParams.witnessValue);
+          witnessScript = signParams.witnessScript;
+          witnessValue = signParams.witnessValue;
+          break;
+        case 'p2sh-p2wsh-p2ms':
+          if (prevOutType !== 'scripthash') {
+            throw new TypeError(`input #${vin} is not of type p2sh-p2wsh-p2ms`);
+          }
+          typeforce(typeforce.Buffer, signParams.witnessScript);
+          typeforce(typeforce.Buffer, signParams.redeemScript);
+          typeforce(typeforce.Satoshi, signParams.witnessValue);
+          witnessScript = signParams.witnessScript;
+          redeemScript = signParams.redeemScript;
+          witnessValue = signParams.witnessValue;
+          break;
+      }
+    } else {
+      throw new TypeError(
+        'TransactionBuilder sign first arg must be TxbSignArg or number',
+      );
+    }
     // TODO: remove keyPair.network matching in 4.0.0
     if (keyPair.network && keyPair.network !== this.network)
       throw new TypeError('Inconsistent network');
diff --git a/ts_src/transaction_builder.ts b/ts_src/transaction_builder.ts
index 0665719..b4d794d 100644
--- a/ts_src/transaction_builder.ts
+++ b/ts_src/transaction_builder.ts
@@ -16,6 +16,21 @@ const typeforce = require('typeforce');
 
 const SCRIPT_TYPES = classify.types;
 
+const PREVOUT_TYPES: Set<string> = new Set([
+  // Raw
+  'p2pkh',
+  'p2pk',
+  'p2wpkh',
+  'p2ms',
+  // P2SH wrapped
+  'p2sh-p2wpkh',
+  'p2sh-p2ms',
+  // P2WSH wrapped
+  'p2wsh-p2ms',
+  // P2SH-P2WSH wrapper
+  'p2sh-p2wsh-p2ms',
+]);
+
 type MaybeBuffer = Buffer | undefined;
 type TxbSignatures = Buffer[] | MaybeBuffer[];
 type TxbPubkeys = MaybeBuffer[];
@@ -50,6 +65,16 @@ interface TxbOutput {
   maxSignatures?: number;
 }
 
+interface TxbSignArg {
+  prevOutScriptType: string;
+  vin: number;
+  keyPair: ECPairInterface;
+  redeemScript?: Buffer;
+  hashType?: number;
+  witnessValue?: number;
+  witnessScript?: Buffer;
+}
+
 function txIsString(tx: Buffer | string | Transaction): tx is string {
   return typeof tx === 'string' || tx instanceof String;
 }
@@ -197,13 +222,102 @@ export class TransactionBuilder {
   }
 
   sign(
-    vin: number,
+    signParams: number | TxbSignArg,
     keyPair: ECPairInterface,
     redeemScript?: Buffer,
     hashType?: number,
     witnessValue?: number,
     witnessScript?: Buffer,
   ): void {
+    let vin: number;
+    if (typeof signParams === 'number') {
+      console.warn(
+        'DEPRECATED: TransactionBuilder sign method arguments ' +
+          'will change in v6, please use the TxbSignArg interface',
+      );
+      vin = signParams;
+    } else if (typeof signParams === 'object') {
+      if (!PREVOUT_TYPES.has(signParams.prevOutScriptType)) {
+        throw new TypeError(
+          `Unknown prevOutScriptType "${signParams.prevOutScriptType}"`,
+        );
+      }
+      typeforce(typeforce.tuple(typeforce.Number, typeforce.Object), [
+        signParams.vin,
+        signParams.keyPair,
+      ]);
+      vin = signParams.vin;
+      keyPair = signParams.keyPair;
+      const prevOutType = (this.__INPUTS[vin] || []).prevOutType;
+      switch (signParams.prevOutScriptType) {
+        case 'p2pkh':
+          if (prevOutType !== 'pubkeyhash') {
+            throw new TypeError(`input #${vin} is not of type p2pkh`);
+          }
+          break;
+        case 'p2pk':
+          if (prevOutType !== 'pubkey') {
+            throw new TypeError(`input #${vin} is not of type p2pk`);
+          }
+          break;
+        case 'p2wpkh':
+          if (prevOutType !== 'witnesspubkeyhash') {
+            throw new TypeError(`input #${vin} is not of type p2wpkh`);
+          }
+          typeforce(typeforce.Buffer, signParams.witnessScript);
+          typeforce(typeforce.Satoshi, signParams.witnessValue);
+          witnessScript = signParams.witnessScript;
+          witnessValue = signParams.witnessValue;
+          break;
+        case 'p2ms':
+          if (prevOutType !== 'multisig') {
+            throw new TypeError(`input #${vin} is not of type p2ms`);
+          }
+          break;
+        case 'p2sh-p2wpkh':
+          if (prevOutType !== 'scripthash') {
+            throw new TypeError(`input #${vin} is not of type p2sh-p2wpkh`);
+          }
+          typeforce(typeforce.Buffer, signParams.witnessScript);
+          typeforce(typeforce.Buffer, signParams.redeemScript);
+          typeforce(typeforce.Satoshi, signParams.witnessValue);
+          witnessScript = signParams.witnessScript;
+          redeemScript = signParams.redeemScript;
+          witnessValue = signParams.witnessValue;
+          break;
+        case 'p2sh-p2ms':
+          if (prevOutType !== 'scripthash') {
+            throw new TypeError(`input #${vin} is not of type p2sh-p2ms`);
+          }
+          typeforce(typeforce.Buffer, signParams.redeemScript);
+          redeemScript = signParams.redeemScript;
+          break;
+        case 'p2wsh-p2ms':
+          if (prevOutType !== 'witnessscripthash') {
+            throw new TypeError(`input #${vin} is not of type p2wsh-p2ms`);
+          }
+          typeforce(typeforce.Buffer, signParams.witnessScript);
+          typeforce(typeforce.Satoshi, signParams.witnessValue);
+          witnessScript = signParams.witnessScript;
+          witnessValue = signParams.witnessValue;
+          break;
+        case 'p2sh-p2wsh-p2ms':
+          if (prevOutType !== 'scripthash') {
+            throw new TypeError(`input #${vin} is not of type p2sh-p2wsh-p2ms`);
+          }
+          typeforce(typeforce.Buffer, signParams.witnessScript);
+          typeforce(typeforce.Buffer, signParams.redeemScript);
+          typeforce(typeforce.Satoshi, signParams.witnessValue);
+          witnessScript = signParams.witnessScript;
+          redeemScript = signParams.redeemScript;
+          witnessValue = signParams.witnessValue;
+          break;
+      }
+    } else {
+      throw new TypeError(
+        'TransactionBuilder sign first arg must be TxbSignArg or number',
+      );
+    }
     // TODO: remove keyPair.network matching in 4.0.0
     if (keyPair.network && keyPair.network !== this.network)
       throw new TypeError('Inconsistent network');
diff --git a/types/transaction_builder.d.ts b/types/transaction_builder.d.ts
index f993807..9441d6b 100644
--- a/types/transaction_builder.d.ts
+++ b/types/transaction_builder.d.ts
@@ -2,6 +2,15 @@
 import { ECPairInterface } from './ecpair';
 import { Network } from './networks';
 import { Transaction } from './transaction';
+interface TxbSignArg {
+    prevOutScriptType: string;
+    vin: number;
+    keyPair: ECPairInterface;
+    redeemScript?: Buffer;
+    hashType?: number;
+    witnessValue?: number;
+    witnessScript?: Buffer;
+}
 export declare class TransactionBuilder {
     network: Network;
     maximumFeeRate: number;
@@ -18,7 +27,7 @@ export declare class TransactionBuilder {
     addOutput(scriptPubKey: string | Buffer, value: number): number;
     build(): Transaction;
     buildIncomplete(): Transaction;
-    sign(vin: number, keyPair: ECPairInterface, redeemScript?: Buffer, hashType?: number, witnessValue?: number, witnessScript?: Buffer): void;
+    sign(signParams: number | TxbSignArg, keyPair: ECPairInterface, redeemScript?: Buffer, hashType?: number, witnessValue?: number, witnessScript?: Buffer): void;
     private __addInputUnsafe;
     private __build;
     private __canModifyInputs;
@@ -26,3 +35,4 @@ export declare class TransactionBuilder {
     private __canModifyOutputs;
     private __overMaximumFees;
 }
+export {};